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1

Synthesis of Novel Restricted Diamines; 2-(1 -Aminocycloalkan-1-YL)ethylamines

Suzuki, Takeshi, Imanishi, Naoki, Itahana, Hirotsune, Watanuki, Susumu, Ohta, Mitsuaki, Mase, Toshiyasu

Journal:

Synthetic Communications

Year:

1998

Language:

english

File:

PDF, 585 KB

english, 1998

2

The Preparation of Mesoionic 5-Imino-3,5-dihydro-1,3-oxazole Derivatives

Sato, Shigeru, Mase, Toshiyasu, Ohta, Masaki

Journal:

Bulletin of the Chemical Society of Japan

Year:

1968

Language:

english

File:

PDF, 1.33 MB

english, 1968

3

2-(3-Pyridyl)thiazolidine-4-carboxamide Derivatives. II. Structure-Activity Relationships and Active Configuration of 2-(3-Pyridyl)thiazolidine-4-carboxamides as Platelet-Activating Factor Receptor Antagonists.

SUZUKI, Takeshi, NAGAOKA, Hitoshi, KONDO, Yutaka, TAKAHASHI, Takumi, TAKEUCHI, Makoto, HARA, Hiromu, SAITO, Munetoshi, YAMADA, Toshimitsu, TOMIOKA, Kenichi, HAMADA, Mamoru, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1998

File:

PDF, 739 KB

1998

4

New .BETA.-adrenoreceptor stimulants. Studies on 3-acylamino-4-hydroxy-.ALPHA.-(N-substituted aminomethyl)benzyl alcohols.

MURASE, KIYOSHI, MASE, TOSHIYASU, IDA, HISASHI, TAKAHASHI, KOZO, MURAKAMI, MASUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1977

File:

PDF, 1.11 MB

1977

5

ChemInform Abstract: A Novel Class of Inhibitors for Human Steroid 5α-Reductase: Phenoxybenzoic Acid Derivatives. Part 1.

Susumu Igarashi, Takenori Kimura, Ryo Naito, Hiromu Hara, Masahiro Fuji, Hiroshi Koutoku, Hiroyuki Oritani, Toshiyasu Mase

Journal:

Year:

2000

File:

PDF, 36 KB

2000

6

Letter to the Editor: NMR structure of human fibronectin EDA

Tatsuya Niimi, Masanori Osawa, Noboru Yamaji, Kunio Yasunaga, Hitoshi Sakashita, Toshiyasu Mase, Akihiro Tanaka, Shigeo Fujita

Journal:

Journal of Biomolecular NMR

Year:

2001

Language:

english

File:

PDF, 135 KB

english, 2001

7

New 1,4-Benzodiazepin-2-one Derivatives as Gastrin/Cholecystokinin-B Antagonists.

SATOH, Masato, KONDOH, Yutaka, OKAMOTO, Yoshinori, NISHIDA, Akito, MIYATA, Keiji, OHTA, Mitsuaki, MASE, Toshiyasu, MURASE, Kiyoshi

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1995

File:

PDF, 1.06 MB

1995

8

Imidazo[2,1-b]benzothiazoles. 2. New immunosuppressive agents

Mase, Toshiyasu, Arima, Hideki, Tomioka, Kenichi, Yamada, Toshimitsu, Murase, Kiyoshi

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 960 KB

english, 1986

9

Novel 5-Hydroxytryptamine (5-HT3) Receptor Antagonists. IV. Synthesis and Pharmacological Evaluation of the Oxidation Products of (-)-(R)-5-((1-Methyl-1H-indol-3-yl)carbonyl)-4,5,6,7 tetrahydro-1H-benzimidazole Hydrochloride (YM060: Ramosetron).

OHTA, Mitsuaki, SUZUKI, Takeshi, NAGASHIMA, Shinya, TOKUNAGA, Tatsuhiro, MIYATA, Keiji, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1996

File:

PDF, 783 KB

1996

10

Dopamine D 3 and D 4 Receptor Antagonists: Synthesis and Structure−Activity Relationships of ( S )-(+)- N -(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl)amino]-2-methoxybenzamide (YM-43611) and Related Compounds

Ohmori, Junya, Maeno, Kyoichi, Hidaka, Kazuyuki, Nakato, Kazuhiro, Matsumoto, Mitsuyuki, Tada, Shoko, Hattori, Hanae, Sakamoto, Shuichi, Tsukamoto, Shin-ichi, Usuda, Shinji, Mase, Toshiyasu

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 286 KB

english, 1996

11

The Effects of YM26818 : 1-(2-Dimethylaminoethyl)-1-(3, 4, 5-trimethoxyphenyl) urea and Derivatives on Pulmonary Surfactant Secretion and Lung Compliance

KIMOTO, Aishi, SAITO, Munetoshi, HIRANO, Yasuno, IWAI, Takaya, TOMIOKA, Kenichi, YAMADA, Toshimitsu, MIYATA, Keiji, MARUYAMA, Tatsuya, IMANISHI, Naoki, HARA, Hiromu, MASE, Toshiyasu

Journal:

YAKUGAKU ZASSHI

Year:

1998

File:

PDF, 651 KB

1998

12

N -[2-[(Substituted chroman-8-yl)oxy]ethyl]-4-(4-methoxyphenyl)butylamines: Synthesis and Wide Range of Antagonism at the Human 5-HT 1A Receptor

Yasunaga, Tomoyuki, Naito, Ryo, Kontani, Toru, Tsukamoto, Shin-ichi, Nomura, Tamako, Yamaguchi, Tokio, Mase, Toshiyasu

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 267 KB

english, 1997

13

Development of a Practical and Scalable Synthetic Route to YM758 Monophosphate, A Novel I f Channel Inhibitor

Yoshida, Shinya, Marumo, Kiyotaka, Takeguchi, Kazuhiro, Takahashi, Takumi, Mase, Toshiyasu

Journal:

Organic Process Research & Development

Year:

2014

Language:

english

File:

PDF, 423 KB

english, 2014

14

A Novel Class of Inhibitors for Human Steroid 5.ALPHA.-Reductase: Synthesis and Biological Evaluation of Indole Derivatives. II.

IGARASHI, Susumu, INAMI, Hiroshi, HARA, Hiromu, FUJII, Masahiro, KOUTOKU, Hiroshi, ORITANI, Hiroyuki, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2000

File:

PDF, 1004 KB

2000

15

Stereochemistry of 2-Amino-1-benzocycloalkanol Derivatives Reaction of 2-Acylamino-1-benzocycloalkanol with Thionyl Chloride or Concentrated Sulfuric Acid

HIRATA, YASUFUMI, YANAGISAWA, ISAO, MASE, TOSHIYASU, KUBO, KAZUO, TAKAHASHI, KOZO, MURAKAMI, MASUO

Journal:

YAKUGAKU ZASSHI

Year:

1977

File:

PDF, 845 KB

1977

16

Synthesis and Pharmacological Characterization of Novel 6-Fluorochroman Derivatives as Potential 5-HT 1A Receptor Antagonists

Yasunaga, Tomoyuki, Kimura, Takenori, Naito, Ryo, Kontani, Toru, Wanibuchi, Fumikazu, Yamashita, Hiroshi, Nomura, Tamako, Tsukamoto, Shin-ichi, Yamaguchi, Tokio, Mase, Toshiyasu

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 312 KB

english, 1998

17

2-(3-Pyridyl)thiazolidine-4-carboxamide Derivatives. III. Synthesis of Metabolites and Metabolism of 2-(3-Pyridyl)thiazolidine-4-carboxamides YM461 and YM264 as Platelet-Activating Factor(PAF) Receptor Antagonists.

SUZUKI, Takeshi, NAGAOKA, Hitoshi, HARA, Hiromu, TAKEUCHI, Makoto, SAITO, Munetoshi, YAMADA, Toshimitsu, TOMIOKA, Kenichi, MATSUMOTO, Hisao, TAKANUKI, Kenichi, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1999

File:

PDF, 775 KB

1999

18

One-Pot Preparation of 1-Substituted Imidazole-2-thione from Isothiocyanate and Amino Acetal

Matsuda, Koyo, Yanagisawa, Isao, Isomura, Yasuo, Mase, Toshiyasu, Shibanuma, Tadao

Journal:

Synthetic Communications

Year:

1997

Language:

english

File:

PDF, 320 KB

english, 1997

19

A Novel Class of Inhibitors for Human Steroid 5.ALPHA.-Reductase. Phenoxybenzoic Acid Derivatives. I.

IGARASHI, Susumu, KIMURA, Takenori, NAITO, Ryo, HARA, Hiromu, FUJII, Masahiro, KOUTOKU, Hiroshi, ORITANI, Hiroyuki, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1999

File:

PDF, 1.02 MB

1999

20

A Novel Class of Inhibitors for Human and Rat Steroid 5.ALPHA.-Reductases: Synthesis and Biological Evaluation of Indoline and Aniline Derivatives. III.

IGARASHI, Susumu, INAMI, Hiroshi, HARA, Hiromu, KOUTOKU, Hiroshi, ORITANI, Hiroyuki, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2000

File:

PDF, 1.17 MB

2000

21

A Scalable Process for the Synthesis of 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5- d ][1]benzazepine Monohydrate and 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic Acid: Two New Key Intermediates for the Synthesis of the AVP Antagonist Conivaptan Hydrochloride

Tsunoda, Takashi, Yamazaki, Atsuki, Mase, Toshiyasu, Sakamoto, Shuichi

Journal:

Organic Process Research & Development

Year:

2005

Language:

english

File:

PDF, 102 KB

english, 2005

22

Biological Activity of Analogues of YM022. Novel (3-Amino Substituted Phenyl)urea Derivatives of 1,4-Benzodiazepin-2-one as Gastrin/Cholecystokinin-B Receptor Antagonists.

SATOH, Masato, OKAMOTO, Yoshinori, KOSHIO, Hiroyuki, OHTA, Mitsuaki, NISHIDA, Akito, AKUZAWA, Shinobu, MIYATA, Keiji, MASE, Toshiyasu, SEMPLE, Graeme

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1996

File:

PDF, 547 KB

1996

23

Effects of YM-13650 on type I to type IV allergic reactions and immune responses in animals.

YAMADA, Toshimitsu, TOMIOKA, Kenichi, MASE, Toshiyasu, MURASE, Kiyoshi

Journal:

Folia Pharmacologica Japonica

Year:

1991

File:

PDF, 7.33 MB

1991

24

Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat

Toshimitsu Yamada, Kenichi Tomioka, Mami Horie, Yasuhiro Sakurai, Hitoshi Nagaoka, Toshiyasu Mase

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 292 KB

english, 1991

25

The Synthesis of Thienotriazolothiazepines

Nagaoka, Hitoshi, Hara, Hiromu, Mase, Toshiyasu

Journal:

Year:

1990

Language:

english

File:

PDF, 71 KB

english, 1990

26

Synthesis of the Selective 5-Hydroxytryptamine 4 (5-HT4) Receptor Agonist (+)-(S)-2-Chloro-5-methoxy-4-(5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl)aniline.

SUZUKI, Takeshi, IWAOKA, Kiyoshi, IMANISHI, Naoki, NAGAKURA, Yukinori, MIYATA, Kenji, NAKAHARA, Hideaki, OHTA, Mitsuaki, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1999

File:

PDF, 570 KB

1999

27

Imidazo[2,1-b]benzothiazoles 3: syntheses and immunosuppressive activities of 2-(m-acyloxyphenyl)imidazo[2,1-b]benzothiazoles

Toshiyasu Mase, Hideki Arima, Kenichi Tomioka, Toshimitsu Yamada, Kiyoshi Murase

Journal:

European Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 436 KB

english, 1988

28

Alternative Synthesis of Dibenzo-and Dipyrido-[1,3]Diazepines from Thioamides and o,o′-Diaminobiaryls

Matsuda, Koyo, Yanagisawa, Isao, Isomura, Yasuo, Mase, Toshiyasu, Shibanuma, Tadao

Journal:

Synthetic Communications

Year:

1997

Language:

english

File:

PDF, 393 KB

english, 1997

29

A New Synthetic Route to YM087, an Arginine Vasopressin Antagonist.

Takashi Tsunoda, Akihiro Tanaka, Toshiyasu Mase, Shuichi Sakamoto

Journal:

Year:

2004

File:

PDF, 59 KB

2004

30

Evaluation of luminal and vessel wall abnormalities in subacute and other stages of intracranial vertebrobasilar artery dissections using the volume isotropic turbo-spin-echo acquisition (VISTA) sequence: A preliminary study

Sakurai, Keita, Miura, Toshiyasu, Sagisaka, Takafumi, Hattori, Manabu, Matsukawa, Noriyuki, Mase, Mitsuhito, Kasai, Harumasa, Arai, Nobuyuki, Kawai, Tatsuya, Shimohira, Masashi, Yamawaki, Takemori, Sh

Journal:

Journal of Neuroradiology

Year:

2013

Language:

english

File:

PDF, 953 KB

english, 2013

31

Pharmacological properties of YM461, a new orally active platelet-activating factor antagonist

Toshimitsu Yamada, Munetoshi Saito, Toshiyasu Mase, Hiromu Hara, Hitoshi Nagaoka, Kiyoshi Murase, Kenichi Tomioka

Journal:

Year:

1991

Language:

english

File:

PDF, 575 KB

english, 1991

32

Ring Closure of N-Substituted N-Acetylglycines with Acid Chlorides

OHTA, Masaki, MASE, Toshiyasu

Journal:

Nippon kagaku zassi

Year:

1968

File:

PDF, 773 KB

1968

33

ChemInform Abstract: A Novel Class of Inhibitors for Human and Rat Steroid 5α-Reductases: Synthesis and Biological Evaluation of Indoline and Aniline Derivatives. Part 3.

Susumu Igarashi, Hiroshi Inami, Hiromu Hara, Hiroshi Koutoku, Hiroyuki Oritani, Toshiyasu Mase

Journal:

Year:

2001

File:

PDF, 38 KB

2001

34

A New Synthetic Route to YM087, an Arginine Vasopressin Antagonist

Tsunoda, Takashi, Tanaka, Akihiro, Mase, Toshiyasu, Sakamoto, Shuichi

Journal:

Year:

2004

Language:

english

File:

PDF, 74 KB

english, 2004

35

2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel Orally Active Antagonists of Platelet-Activating Factor (PAF).

NAGAOKA, Hitoshi, HARA, Hiromu, SUZUKI, Takeshi, TAKAHASHI, Takumi, TAKEUCHI, Makoto, MATSUHISA, Akira, SAITO, Munetoshi, YAMADA, Toshimitsu, TOMIOKA, Kenichi, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1997

File:

PDF, 868 KB

1997

36

New thiazole derivatives as potent and selective 5-hydroxytriptamine 3 (5-HT3) receptor agonists for the treatment of constipation

Naoki Imanishi, Kiyoshi Iwaoka, Hiroyuki Koshio, Shin-ya Nagashima, Ken-ichi Kazuta, Mitsuaki Ohta, Shuichi Sakamoto, Hiroyuki Ito, Shinobu Akuzawa, Tetsuo Kiso, Shin-ichi Tsukamoto, Toshiyasu Mase

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 267 KB

english, 2003

37

Solution structure of Calmodulin-W-7 complex: the basis of diversity in molecular recognition

Masanori Osawa, Mark B Swindells, Jun Tanikawa, Toshiyuki Tanaka, Toshiyasu Mase, Toshio Furuya, Mitsuhiko Ikura

Journal:

Journal of Molecular Biology

Year:

1998

Language:

english

File:

PDF, 607 KB

english, 1998

38

Absolute configurations of four isomers of 3-formamido-4-hydroxy-.ALPHA.-[[N-(p-methoxy-.ALPHA.-methylphenethyl)amino]methyl]benzyl alcohol, a potent .BETA.-adrenoreceptor stimulant.

MURASE, KIYOSHI, MASE, TOSHIYASU, IDA, HISASHI, TAKAHASHI, KOZO, MURAKAMI, MASUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1978

File:

PDF, 939 KB

1978

39

Unambiguous synthesis of 1-(7-indenyloxy)-3-isopropylamino-2-propanol hydrochloride and its 4-indenyloxy isomer, potent .BETA.-adrenergic blocking agents.

MURASE, KIYOSHI, TAMAZAWA, KAZUHARU, MASE, TOSHIYASU, TACHIKAWA, SHIRO, SHIOBARA, YUICHI, TAKAHASHI, KOZO, MURAKAMI, MASUO

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1976

File:

PDF, 439 KB

1976

40

ChemInform Abstract: A Novel Class of Inhibitors for Human Steroid 5α-Reductase: Synthesis and Biological Evaluation of Indole Derivatives. Part 2.

Susumu Igarashi, Hiroshi Inami, Hiromu Hara, Masahiro Fujii, Hiroshi Koutoku, Hiroyuki Oritani, Toshiyasu Mase

Journal:

Year:

2000

File:

PDF, 32 KB

2000

41

Novel 5-Hydroxytryptamine 4 (5-HT4) Receptor Agonists. Synthesis and Gastroprokinetic Activity of 4-Amino-N (2-(1-aminocycloalkan-1-yl)ethyl)-5-chloro-2 methoxybenzamides.

SUZUKI, Takeshi, IMANISHI, Naoki, ITAHANA, Hirotsune, WATANUKI, Susumu, MIYATA, Keiji, OHTA, Mitsuaki, NAKAHARA, Hideaki, YAMAGIWA, Yoko, MASE, Toshiyasu

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1998

File:

PDF, 1.17 MB

1998

42

Synthetic Studies of 4-Oxo- and 4-Imino-3,4-dihydro-1,3-oxazoles

Chinone, Akiko, Sato, Shigeru, Mase, Toshiyasu, Ohta, Masaki

Journal:

Bulletin of the Chemical Society of Japan

Year:

1969

Language:

english

File:

PDF, 6.13 MB

english, 1969

43

ChemInform Abstract: Synthesis of the Selective 5-Hydroxytryptamine 4 (5-HT4) Receptor Agonist (+)-(S)-2-Chloro-5-methoxy-4- [5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl]aniline.

Takeshi Suzuki, Kiyoshi Iwaoka, Naoki Imanishi, Yukinori Nagakura, Keiji Miyata, Hideaki Nakahara, Mitsuaki Ohta, Toshiyasu Mase

Journal:

Year:

1999

File:

PDF, 35 KB

1999

44

Synthesis of New Indene Derivatives with β-Adrenergic Blocking Properties

MURASE, KIYOSHI, NIIGATA, KUNIHIRO, MASE, TOSHIYASU, MURAKAMI, MASUO

Journal:

YAKUGAKU ZASSHI

Year:

1972

File:

PDF, 761 KB

1972

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